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Science Studies: Construction of Analogy-Based Research Programs : The Lock-And-Key Analogy in 20th Century Biochemistry by Rebecca Mertens (2019, Trade Paperback)
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About this product
Product Identifiers
PublisherTranscript Verlag
ISBN-103837644421
ISBN-139783837644425
eBay Product ID (ePID)9038545912
Product Key Features
Number of Pages224 Pages
Publication NameConstruction of Analogy-Based Research Programs : The Lock-And-Key Analogy in 20th Century Biochemistry
LanguageEnglish
Publication Year2019
SubjectPhilosophy & Social Aspects, Epistemology, Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), History
TypeTextbook
AuthorRebecca Mertens
Subject AreaPhilosophy, Science
SeriesScience Studies
FormatTrade Paperback
Dimensions
Item Height0.1 in
Item Weight11.3 Oz
Item Length0.9 in
Item Width0.6 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN2019-391655
ReviewsThis work would be appropriate for anyone interested in the philosophy of science or specifically in the work of Fischer, Ehrlich, or Pauling.
TitleLeadingThe
IllustratedYes
Table Of ContentFrontmatter 1 Table of contents 5 Preface 7 1 The lock-and-key analogy and its influence on 20th century biochemistry 9 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907 39 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930 77 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960 133 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs 173 6 Concluding remarks on the construction of analogy-based research programs 199 Literature 205
SynopsisWhen the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling., When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modeling., Rebecca Mertens explains the appeal of the lock-and-key analogy to investigate the relation between chemical structure and biological specificity by its role in model building and in the construction of long-term, crossgenerational research programs.
LC Classification NumberQP514.2.M46 2019
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