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Hereditary Basis of Childhood Cancer by David Malkin (2021, Hardcover)
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About this product
Product Identifiers
PublisherSpringer International Publishing A&G
ISBN-103030744469
ISBN-139783030744465
eBay Product ID (ePID)27050408626
Product Key Features
Number of PagesXi, 491 Pages
LanguageEnglish
Publication NameHereditary Basis of Childhood Cancer
SubjectGenetics, Pharmacology, Research
Publication Year2021
TypeTextbook
AuthorDavid Malkin
Subject AreaMedical
FormatHardcover
Dimensions
Item Weight32.3 Oz
Item Length9.3 in
Item Width6.1 in
Additional Product Features
TitleLeadingThe
Number of Volumes1 vol.
IllustratedYes
Table Of Content1: Li-Fraumeni Syndrome.- 2: Pediatric Central Nervous System Cancer Predisposition.- 3: Rhabdoid Tumors.- 4: Neurofibromatosis.- 5: Pheochromocytoma and Paraganglioma syndromes.- 6: Wilms tumor.- 7: Hereditary Overgrowth Syndromes.- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions.- 9: DICER1 Syndrome.- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes.- 11: Inherited Risk for Childhood Leukemia.- 12: Inherited pediatric cancer in low and intermediate resource countries.- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research.- 14: Genetic counseling and testing.- 15: Psychosocial aspects of childhood cancer genetics.- 16: Recognition of cancer predisposition syndromes.
SynopsisThis volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, butwhere the clinical manifestations of these disorders are prevalent., This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the 'disease-related' chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where 'modern' technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
LC Classification NumberRB155-155.8
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