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Macrolide Antibiotics by H.A. Kirst (English) Paperback Book
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Located in: Fairfield, Ohio, United States
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eBay item number:386714569070
Item specifics
- Condition
- Brand New: A new, unread, unused book in perfect condition with no missing or damaged pages. See all condition definitionsopens in a new window or tab
- ISBN-13
- 9783034894388
- Book Title
- Macrolide Antibiotics
- ISBN
- 9783034894388
- Series
- Milestones in Drug Therapy Ser.
- Publication Year
- 2012
- Type
- Textbook
- Format
- Trade Paperback
- Language
- English
- Publication Name
- Macrolide Antibiotics
- Item Length
- 9.3in
- Publisher
- Springer Basel A&G
- Item Width
- 6.1in
- Item Weight
- 18.2 Oz
- Number of Pages
- X, 323 Pages
About this product
Product Information
There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery- thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy- cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro- lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
Product Identifiers
Publisher
Springer Basel A&G
ISBN-10
3034894384
ISBN-13
9783034894388
eBay Product ID (ePID)
176379164
Product Key Features
Publication Name
Macrolide Antibiotics
Format
Trade Paperback
Language
English
Series
Milestones in Drug Therapy Ser.
Publication Year
2012
Type
Textbook
Number of Pages
X, 323 Pages
Dimensions
Item Length
9.3in
Item Width
6.1in
Item Weight
18.2 Oz
Additional Product Features
Number of Volumes
1 Vol.
Lc Classification Number
Rm300-666
Table of Content
to the macrolide antibiotics.- Macrolides: a clinical overview.- Pharmacokinetics/pharmacodynamics of macrolides.- Cellular accumulation of macrolide antibiotics. Intracellular bioactivity.- Clarithromycin and new derivatives of erythromycin.- Azithromycin and novel azalides.- Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within gram-positive cocci.- Novel macrolide derivatives active against resistant pathogens.- Polyketide diversity.- Biosynthesis of the macrolide antibiotic, tylosin.- Activity of macrolides against mycobacteria.- Chlamydia pneumoniae and asthma and atherosclerosis: role of macrolides...- Activity of macrolides in sexually transmitted diseases.- Helicobacter pylori and macrolides.- Effects of macrolide antibiotics on ribosome function.- Mechanisms of resistance to macrolides, lincosamides, and ketolides.
Copyright Date
2002
Topic
Immunology, Pharmacology, Diseases
Dewey Decimal
615/.329
Intended Audience
Scholarly & Professional
Dewey Edition
21
Illustrated
Yes
Genre
Medical
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Item as described. Glad to find these as they aren’t available in the US.